SUBUTEX

 

SUBUTEX

SUBUTEX (buprenorphine) sublingual tablet is an uncoat oval white flat bevelled edge tablet, deboss  . With an alphanumeric word identifying the product and strength on one side . Also , It contains buprenorphine HCl, a partial agonist at the mu-opioid receptor . More so , it is available in two dosage strengths, 2 mg buprenorphine  . The 8 mg buprenorphine (as the free base, equivalent to 2.16 mg buprenorphine hydrochloride USP and 8.64 mg buprenorphine hydrochloride USP). Each tablet also contains lactose, mannitol, cornstarch, povidone K30, citric acid, sodium citrate and magnesium stearate. subutex 

Further More , Chemically, buprenorphine HCl is (2S)-2-[17-Cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol hydrochloride. It has the following chemical structure:

 

 

SUBUTEX (buprenorphine) Structural Formula Illustration

 

Further More , Buprenorphine HCl has the molecular formula C29 H41 NO4 • HCl and the molecular weight is 504.10 . It is a white or off-white crystalline powder, sparingly soluble in water, freely soluble in methanol . Also soluble in alcohol and practically insoluble in cyclohexane.

SUBUTEX

  • Generic Name: buprenorphine
  • Brand Name: Subutex

Uses

Buprenorphine is use to treat dependence/addiction to opioids. Buprenorphine belongs to a class of drugs call mixed opioid agonist-antagonists. It helps prevent withdrawal symptoms cause by stopping other opioids. It is use as part of a complete treatment program for drug abuse (such as compliance monitoring, counseling, behavioral contract, lifestyle changes).

How to use Subutex Tablet, Sublingual

Read the Medication Guide provide by your pharmacist before you start using sublingual buprenorphine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Use this medication as directed by your doctor, usually once daily. Place the medication under your tongue for 5 to 10 minutes and let it dissolve completely. If you are prescribe more than one tablet each day, you may place all of the tablets under your tongue at once or place two tablets at a time under your tongue. Do not swallow or chew this medication. It will not work as well.

Buprenorphine alone is usually used for the first 2 days after you have stopped all other opioids. It is usually given in your doctor's office. Your doctor will then switch you to the combination buprenorphine/naloxone medication for maintenance treatment. The combination with naloxone works the same way as buprenorphine alone to prevent withdrawal symptoms. It is combine with naloxone to prevent misuse (injection) of the medication.

Buprenorphine works best when the first dose is start after signs of opioid withdrawal have begun. Buprenorphine can cause withdrawal symptoms if started too soon after your last opioid use. Follow your doctor's instructions for your treatment plan.

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